ABSTRACT
Lipoprotein ( a ) [ Lp ( a ) ] is considered a causal risk factor for the formation and development of atherosclerosis ( AS).High plasma levels of Lp ( a) is recognized as a predictor of coronary heart disease. However, the pathogenic mechanisms of Lp ( a ) are still unknown. Recent studies demonstrated that a key role in the proatherogenic effects of Lp ( a ) may be linked to its oxidized phospholipids ( OxPL) content.Lipoprotein-associated phospholipase A 2 ( Lp-PLA2 ) is another important factor in Lp( a) functionality.OxPL are hydrolyzed by Lp-PLA2 into lysophosphatidylcholine ( lyso-PC) and oxidized free fatty acid(OxFFA), which are important inflammatory factors on promoting the occurrence and development of AS.The present review article describes Lp-PLA2 hydrolyzing OxPL associated with Lp (a). The process induces inflammatory factors , which promote development of AS .OxPL and Lp-PLA2 can be used as new targets of cardiovascular diseases , which have clinical application value to predict potential cardiovascular diseases .
ABSTRACT
Objective To investigate the relationship between lipoprotein-associated phospholipase A2(Lp-PLA2) activity and the severity of coronary artery diseases .Methods A case-control study was conducted to select 231 patients with positive coronary angiography results in Beijing Huaxin Hospital .They were divided into two groups (untreated goup:147 cases; the medication group:84 cases) according to whether taking statins.99 cases were included in the healthy control group .In the untreated group, all male patients were grouped according to the number of diseased coronary branches (43 cases were in single vessel lesion group and 52 cases were in multi vessel disease group ) or to the Gensini score (32 cases were in low score group, 36 cases were in middle score group and 27 cases were in high score group ).The clinical data were collected by detecting serum atherosclerotic markers such as Lp-PLA2, total cholesterol (CHOL), low-density lipoprotein (LDL).The number of vessels involved in coronary artery disease , the position of the lesion and the degree of stenosis were confirmed by percutaneous coronary intervention ( PCI).Statistical evaluations were performed using t-test, variance analysis, Mann-Whitney U test and Spearman correlation analysis.Results The differences among untreated group , the medication group and the control group were statistically significant, of which the Lp-PLA2 level was (561.9 ±158.5) U/L, (373.2 ±124.7) U/L and (467.4 ±130.4) U/L respectively.Compared with single branch disease group , the Lp-PLA2 level in the multiple branches disease group was increased dramatically .Additionally, the level of Lp-PLA2 in high Gensini score group was (618.7 ±165.4) U/L, significantly higher than the low score group (517.3 ± 191.7) U/L.Conclusion Lp-PLA2 activity was associated with the severity of Coronary Artery Diseases, which can provide the evidence for the follow-up treatment programs.